'Allergic' Reaction After Exposure to Toxic Fumes in a‘Top Gun’Jet
'Allergic' Reaction After Exposure to Toxic Fumes in a‘Top Gun’Jet
Jet fuel in the blood?
Miles Teller garnered worldwide success starring in the hit action film Top Gun: Maverick - in this short clip taken from an interview on the Seth Myers show he talks about his reaction following exposure to toxic fumes in a ‘Top Gun’ jet.
The story in the video sounds hilarious doesn’t it - especially Tom Cruise’s response.
But, here it comes: Did you know that aircrew working commercial jets are exposed to those fumes every time they go to work and that reactions to the toxic substances in those fumes in aircraft cabin breathing air can occur at any time?
Miles Teller is very fortunate that he chose to be an actor and not an airline pilot, still, he reacted to a once-off flight, that has to get you thinking.
It all begins with ‘TILT’.
What is TILT?
‘Toxicant-induced loss of tolerance (TILT) is a two-stage disease mechanism first described in the 1990s and characterized by multisystem symptoms and new-onset intolerances that develop in a subset of individuals following major chemical exposure events or repeated low-level exposures.’ (read here)
The term ‘Aerotoxic Syndrome’ was coined in 1999 (Balouet, Hoffman & Winder) to highlight the actual connection (aero = aeroplane and toxic = toxic fumes) to differentiate between aircrew constantly exposed to a certain type/mixture of toxic fumes and non-career flying population.
”Aerotoxic syndrome is a rarely recognized and poorly defined illness resulting from exposure to products of oil combustion in commercial aircraft bleed air systems. The pathophysiology of this syndrome is not well understood. A 42-year-old male pilot developed duty-limiting symptoms consistent with aerotoxic syndrome following exposure to airline cabin fumes and recurrence of symptoms following re-exposure despite apparent full recovery from the initial exposure event. Given his persistent symptoms and concern for immediate debilitation/incapacitation, if re-exposed, the pilot was deemed medically unqualified for return to commercial piloting duties, and a disability determination was made.” (sic © from:) Prolonged Disability Following Re-Exposure after Complete Recovery from Aerotoxic Syndrome: A Case Report (December 2023)
Toxic Triggers Leading to TILT and Nervous System Injury - an excerpt from my paper:
Exposure Assessment and Timeline of the gradual loss of tolerance to chemical substances. ( Bearnairdine Beaumont January 2021).
Toxic exposure can have occurred unnoticed for many years in the past—some toxic substances deposit in the organs and bones, and others in fatty tissues. The presence of synthetic chemicals in the body's fat cells slows down the natural detoxification process. Over time, this can lead to the body carrying a toxic load, also known as toxic body burden. Chemicals vary widely in the timescale it takes for their potency to reduce - known as the chemical half-life.
Even at low levels, chronic exposure to toxic substances increases the body's toxic inflammatory reaction. The body will do its best to deal with foreign or 'xenobiotic' invaders. However, at some stage, it will run out of steam and ill-health results.
A person's susceptibility to chemicals depends on many factors. In some cases by the genes they inherit and others by epigenetic effects that can be changed by environmental factors. Whether a person is ill or not and whether a toxic event has happened in the organism can be shown scientifically by finding a metabolite or original substance in human biomonitoring or fatty tissue biopsies. Alternatively, by provocation tests. A validated analysis and exposure assessment that explicitly prove the relationship of the substance type or noxious agent (pollutant) and the provocation effects are required.’ (to read the full paper go here)
There’s more from others of course:
‘The marker of chronic OP poisoning is sensitization: heightened sensitivity to low exposures of the initiating agent and cross-sensitization or multiple chemical sensitivity (MCS) to a range of unrelated chemicals, including other pesticides, solvents, perfumes, and certain foods. Sensitization can be defined as chemical kindling and is inter-transferable with experimental electrical kindling. Kindling is an amplification process where the initial stimulus has no effect. but repetitive stimulation of a brain area, usually in the limbic system induces abnormal discharges and release of glutamate at high frequencies, mediated by N-Methyl-D-Aspartate (NMDA) receptors. Electrical kindling culminates in seizures. Chemical kindling induces dysfunction of sensory reception and emotional responses via the amygdala. impairment of memory and cognition via the hippocampus and interference with odor discrimination via the olfactory lobe. Alterations in motor, endocrine, autonomic and immune function are relayed through the hypothalamus, midbrain and brain stem.
(…..)”
“The organophosphates used in the operation of aircraft can cause the same effects on human health as organophosphate pesticides.
They are also confirmed to be endocrine-disrupting chemicals and are known to cause mitochondrial dysfunction as well as cytotoxicity and genotoxicity.
117 of the chemicals detected in aircraft cabin air to date are endocrine-disrupting chemicals.” (read the full OPRUS - Fullerton article here ).
There isn’t anything ‘cool’ about being exposed to these chemicals or having them in your blood and throughout your organs.
Fortunately, Miles seems to have made a complete recovery since his exposure while working on the film. Interesting though how his physician seemed to know what to look for…
For further information on Aerotoxic Syndrome, a medical protocol, crew and passenger testimonies affected by fumes, documentaries, past and current legal cases - NOTE! Several cases have been won in 2023 in FRANCE/Europe, - and much more - please visit:
UNFILTERED https://www.unfiltered.vip/
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